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- Bivalent vaccine more effective at preventing symptomatic disease @ יואל קסלר .קוםBivalent vaccine more effective at preventing symptomatic disease @ יואל קסלר .קום
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- Review of Breast Cancer Risk for Primary Care @ יואל קסלרIn this post we present a nice review article from CCJM on the Review of Breast Cancer Risk for Primary Care @ יואל קסלר
- Study Shows People Infected With COVID-19 Are At Higher Risk Of Brain Other Neurological Disorders @ יואל קסלרStudy Shows People Infected With COVID-19 Are At Higher Risk Of Brain Other Neurological Disorders @ יואל קסלר
- Nearly 10% of Americans Suffer from Depression @ יואל קסלרIn this post at יואל קסלר . קום we discuss newly published data that shows early 10% of Americans Suffer from Depression @ יואל קסלר
- Updated COVID-19 Vaccine Booster Shots Restore Antibody Levels @ יואל קסלרUpdated COVID-19 Vaccine Booster Shots Restore Antibody Levels @ יואל קסלר
- Review of GLP1 receptor antagonists @ יואל קסלרוIn this post "Review of GLP1 receptor antagonists @ יואל קסלר " we present a link to a nice review from CCJM on the role of GLP1 in the treatment of diabetes mellitus
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- Neuropsychiatric sequelae of long COVID 19 @ יואל קסלר .comAt Neuropsychiatric sequelae of long COVID 19 @ יואל קסלר .com, we present published data from the journal Brain, Behavior, & Immunity -Health
- Prevalence of chronic conditions in young adults @ יואל קסלר .comIn this post, prevalence of chronic conditions in young adults @ יואל קסלר .com, we present a new article from the CDC.
- New data that frequent exercise significantly reduces risk of death @יואל קסלרNew data that frequent exercise significantly reduces risk of death @יואל קסלר
- ARBs may decrease risk of Dementia @ יואל קסלרARBs may decrease risk of Dementia in patients with MCI @ יואל קסלר .com
- Myocarditis and Pericarditis after COVID 19 mRNA vaccine: New published dataAt יואל קסלר .com we reprint ew data on risks of Myocarditis and Pericarditis after COVID 19 mRNA vaccine published in JAMA
- USPTF vitamin supplementation recommendations at יואל קסלרUSPTF vitamin supplementation recommendations at יואל קסלר discusses new guidelines for dietary vitamin supplement use
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- Progression from pre-diabetes to diabetes @ יואל קסלר .comIn this article at Progression from pre-diabetes to diabetes @ יואל קסלר .com we present recently published data on diabetes progression risk
- Risks of Long COVID @ יואל קסלר .comRisks of long COVID and post acute disease in vaccinated and unvaccinated patients
- COVID 19 and Cognitive dysfunctionIn this post at COVID 19 and Cognitive dysfunction @יואל קסלר .com we discuss new data published in the Lancet eCliniclamedicine about COVID19 and cognitive dysfunction
- Can exercise reduce depression – יואל קסלרCan exercise reduce depression – יואל קסלר?
- Vitamin D supplementation @ יואל קסלרVitamin D supplementation @ יואל קסלר
- Avocado consumption may reduce cardiovascular disease @ יואל קסלרAvocado consumption may reduce cardiovascular disease @ יואל קסלר
- Can Coffee reduce CV risk @ יואל קסלרCan Coffee reduce CV risk @ יואל קסלר
- Anticoagulation and dementia @ יואל קסלרAnticoagulation in atrial fibrillation and reduced risk of dementia @ יואל קסלר
- Light Exposure and Metabolic dysfunction @ יואל קסלרLight Exposure and Metabolic dysfunction @ יואל קסלר
- Mental Health Survey @ יואל קסלרMental Health Survey Data from the APA @ יואל קסלר .com
- Long COVID @ יואל קסלר .comLong COVID at יואל קסלר .com
- Statins as Primary Prevention @ יואל קסלרUSPTF Recommendations for Statins as primary prevention of CV disease At Statins as Primary Prevention @ יואל קסלר .com we are presenting newly released data from the United States Preventative Task Force on the use Read more…
- Exercise benefits in elderly @יואל קסלרExercise benefits in elderly @ יואל קסלר .com
- Waning efficacy of COVID mRNA vaccines @ יואל קסלר .comWaning efficacy of COVID mRNA vaccines @ יואל קסלר .com
- Antihypertensives and Dementia – יואל קסלר .comAntihypertensives and Dementia – יואל קסלר .com we discuss new data that discusses how some antihypertensive meds can prevent dementia
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- יואל קסלר .com Sequelae of Non-Severe COVIDNew article on long term sequelae of COVID 19 at יואל קסלר .com Sequelae of Non-Severe COVID
- Discontinuing Antidepressants @ יואל קסלר .comDiscontinuing Antidepressants @ יואל קסלר .com
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- NEJM Articles of the year יואל קסלר.comNEJM Articles of the year יואל קסלר.com
- CRISPR and DMD @ יואל קסלר .comWhat is DMD? @ יואל קסלר .com CRISPR and DMD @ יואל קסלר .com DMD or Duchenne Muscular Dystrophy is a X linked recessive genetic disease that leads to muscle wasting, a loss of the Read more…
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- COVID vaccine at יואל קסלר .comIn this post at Covid vaccine at יואל קסלר .com we present an article published on STAT describing the rise and fall of the J&J COVID vaccine
- Hyperlipidemia Overview at יואל קסלר .comIn this post at יואל קסלר .com we represent a great summary of the ACC/AHA hyperlipidemia treatment guidelines as published in CCJM
- Mucormycosis and COVID @ יואל קסלר .comNew update from CDC @ Mucormycosis and COVID @ יואל קסלר .com
- CRISPR News @ יואל קסלר .comNew data on hematologic disease gene editing therapy at CRISPR News @ יואל קסלר .com
- יואל קסלר .com- Influenza Vaccine updateUpdate on the 2021-2022 influenza vaccine at יואל קסלר .com- Influenza Vaccine update
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- CGRP and Migraine at יואל קסלר .comThis is a discussion of the pathophysiology of Migraine at יואל קסלר .com and implications of new treatment options
- יואל קסלר Omicron updateNew updates on the spread of the covid 19 omicron variant at יואל קסלר .com
- יואל קסלר Covid Omicron Variant updateUpdates on the COVID 19 variant from WHO @ יואל קסלר .com
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- ומיגרינה CGRP @ יואל קסלרMigraine and CGRP
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- Music and the brain @ יואל קסלר musicHow does the brain process music?
- About דר יואל קסלר siteAt יואל קסלר.com we aim to provide resources to assist healthcare professionals and drug safety experts. We collect and consolidate information from hundreds of professional organizations and regulatory authority websites to help promote best practice Read more…
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Migraine and the role of CGRP by יואל קסלר
Migraine is a disease that is extremely prevalent in the population. It is most frequently divided into 2 types; migraine with aura and migraine without aura. It can occur as episodic migraine which is defined as less than 15 migraine days per month, and chronic migraine that occurs on 15 or more days a month. Migraines can be triggered by many factors including certain types of food, alcohol, sleep deprivation, and stress. Additionally, genetic factors are thought to play a significant role in a person's risk for developing migraines.
CGRP or calcitonin gene related peptide has been well studied and found to play an important role in both the brain and peripheral nervous system in the development and evolution of a migraine. As such, it has long been thought to be an ideal target for migraine therapy.
Currently, there are a number of medications available which target the CGRP pathway. The best studied ones are the monoclonal antibodies. These antibodies target either the CGRP ligand (fremanezumab, galcanezumab, epitinezumab) or the CGRP receptor (erenumab). These are administered by subcutaneous injection or intravenously (epitinezumab) Additionally, an oral class referred to as gepants was recently approved for marketing in some countries.
All these drugs have been shown to be effective in preventing migraines. The most common side effects are local allergic reactions. Most are mild, but severe allergic reactions have been reported with all the drugs. Additionally, erenumab has been reported to cause high blood pressure and constipation which in some cases have been serious.
Additional information can be found here:
CGRP antagonists for decreasing migraine frequency: New options, long overdue Julia Bucklan, DO and Zubair Ahmed, MD
Additional articles on this topic are available here.
Music and the Brain @ יואל קסלר Blog
Music has been an essential component in human cultural development. Early musical instruments made out of bone were found by archeologists dating as early as 40,000 years ago. It has long been thought that the brain pathways that allow the learning of certain components of music such as absolute pitch can only be learned by the young developing brain. After a certain age these pathways become less "plastic" and we are less able to learn. A study by researchers in France, Canada, and the US suggest that these pathways may be able to be reopened. They found that young men who were given a drug called valproate, which is used to treat epilepsy, learned to identify pitch much better that those receiving placebo. Read the article here.
In this post at יואל קסלר .com we present a fascinating video where expert neuroscientists who study how human perceive, process, and understand music discuss the current thinking in the field. Additionally, famous musician Bobby Mc Ferrin demonstrates how we all have innate ability to appreciate and anticipate musical progressions and how this is seen from early human civilizations. It also discusses how music has evolved differently in different cultures around the world and how our ability to reproduce and anticipate musical progressions differs depending on the type of music we are used to listening to.
Additionally, the more we learn about how the brain works we understand its potential role in healing. The following from Harvard University explains:
Activating the Brain
The process by which we’re able to perceive a series of sounds as music is incredibly complex, Silbersweig and BWH psychiatry colleague Samata Sharma, MD, explained in a 2018 paper on the neurobiological effects of music on the brain. It starts with sound waves entering the ear, striking the eardrum, and causing vibrations that are converted into electric signals. These signals travel by sensory nerves to the brainstem, the brain’s message relay station for auditory information. Then they disperse to activate auditory (hearing) cortices and many other parts of the brain. It is noteworthy that different parts of the brain are activated, depending on the type of music—for example, melodic versus dissonant—and whether we are listening, playing, learning, or composing music (see related box).
Music can alter brain structure and function, both after immediate and repeated exposure, according to Silbersweig. For example, musical training over time has been shown to increase the connectivity of certain brain regions. “If you play an instrument like the violin,” he said in a recent Zoom interview, “the areas in your brain that are associated with the frequencies of the violin are more stimulated and the synaptic connections are richer.”
Healing Power of Music
These changes in brain circuitry and connectivity suggest opportunities to activate certain regions to promote healing, Silbersweig says. He and Haddad look forward to using cutting-edge brain research to build on what’s already known about the therapeutic power of music for patients with dementia, depression, and other neurological conditions. The pair note, for instance, that playing a march or other rhythmic piece for people with Parkinson’s disease stimulates the brain circuits that get them physically moving. Similarly, people with short-term memory loss from Alzheimer’s disease often recognize familiar songs like “Happy Birthday” because “that memory’s encoded into their brain’s long-term memory,” Haddad notes.
Haddad witnessed this response during high school and college while performing for patients in hospitals and assisted living facilities. “You have these patients who are essentially sedated, lying down, eyes closed, not able to communicate,” she recalls. “And when you play a song that they recognize from their youth, their eyes light up. They’re sitting up, and they’re smiling. It’s just incredible.”
See more here.