ASSOCIATION OF CANNABIS USE DISORDER WITH RISK OF CORONARY ARTERY DISEASE @ יואל קסלר . קום
במאמר זה שנדפס מחדש ב יואל קסלר .קום, בקבוצה גדולה ברמת אוכלוסייה, שימוש תכוף אך לא מזדמן בקנאביס היה קשור לסיכון מוגבר למחלת עורקים כליליים
Background
In this post " ASSOCIATION OF CANNABIS USE DISORDER WITH RISK OF CORONARY ARTERY DISEASE @ יואל קסלר . קום " we reprint data from a new article in the Journal of the American College of Cardiology that demonstrates that "there is conflicting evidence on the association of cannabis use and coronary artery disease (CAD). We investigated the causal association of genetic liability to cannabis use disorder and risk of CAD.
Methods
Using the All of Us cohort, a large population level cohort from 340 inpatient and outpatient sites across the United States (N = 175,000), we associated cannabis usefrequency with CAD. We then performed a mendelian randomization analysis using summary statistics from genome wide association studies (GWAS) of cannabis use disorder (CUD) and lifetime cannabis use.
Results
Compared to never-users (N = 39,678), daily cannabis users (N= 4,736) had an increased odds of developing CAD (OR = 1.34, 95% CI: 1.13 – 1.58, P = 0.001) adjusted for age, sex, hypertension, hyperlipidemia, type 2 diabetes, body mass index, education, insurance status, and cigarette use. Using two-sample MR, genetic liability to CUD was associated with an increased risk of CAD (OR = 1.05, 95% CI: 1.02 – 1.09, P = 0.001). No evidence of pleiotropy, outliers, or violation of MR assumptions was found. The association of CUD and CAD was independent of alcohol and tobacco use in multivariable MR analysis (OR = 1.04, 95% CI: 1.01 – 1.07).
Conclusion
In a large population-level cohort, frequent but not occasional cannabis use was associated with an increased risk of CAD. In MR analysis, CUD, but not occasional use was associated with CAD, independent of tobacco use."
For access to the full article follow this link
For more interesting articles like "ASSOCIATION OF CANNABIS USE DISORDER WITH RISK OF CORONARY ARTERY DISEASE @ יואל קסלר . קום " check out our blog here.
If you enjoyed this article – ASSOCIATION OF CANNABIS USE DISORDER WITH RISK OF CORONARY ARTERY DISEASE @ יואל קסלר . קום check out our other pages.
