NEJM releases free version of the articles of the year
At NEJM Articles of the year יואל קסלר .com we are posting the recent release from the New England Journal of Medicine. The prestigious journal has published, free of charge, the articles presenting clinical trial data that most impacted the medical world in 2021.
Contents of NEJM Articles of the year יואל קסלר.com
The topics presented include updates in this post at NEJM Articles of the year יואל קסלר.com include:
- Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
- Once-Weekly Semaglutide in Adults with Overweight or Obesity
- Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis
- Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue
- Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria
- CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
- Atogepant for the Preventive Treatment of Migraine
- Effect of Salt Substitution on Cardiovascular Events and Death
- Maintenance or Discontinuation of Antidepressants in Primary Care
- Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension
- Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients
This is a summary of the publication from the Editor in Chief of the NEJM:
"One Original Article, on a four-month rifapentine-based regimen for tuberculosis, showed that four months of treatment can be similar to standard therapy for six months. According to data published this year from the Global Fund, about 1 million fewer people were treated for TB in 2020 because of the pandemic. The prospect of an even shorter short-course treatment is therefore welcome news.
Other Original Articles were built on ingenuity. One study reported that rates of dengue fever dropped in the city of Yogyakarta, Indonesia, where Wolbachia-infected mosquito populations were released. Infection with the endosymbiont Wolbachia pipientis bacteria made these mosquitoes resistant to dengue; this resistance ended up protecting the people in that community.
Another pioneering trial reported on a paralyzed man with anarthria (the inability to articulate speech), who was able to communicate using a model that decoded words and sentences in real time from cortical activity generated when he attempted to speak. A video provided by the authors, and available at NEJM.org, demonstrated this remarkable achievement.
Also included in this collection are two practice-changing articles that addressed the use of race in the estimation of kidney function. Many institutions had already stopped using a Black race coefficient in calculating the eGFR because it could result in inequitable treatment. These articles proposed more equitable equations and provided evidence that equations based on cystatin C have greater predictive accuracy than those derived from serum creatinine with a race coefficient. Even with this modification, says the related editorial, estimates of GFR are, by their nature, imperfect. “Most important, however,” the editorial concludes, “is that estimates do no harm but rather help us care for all patients equally.”
The full file of all articles including associated editorials can be found here.
Check back to NEJM Articles of the year יואל קסלר.com for more updates as they are released.